M0
  M1
  M2
  M3
  M4
  M5
  M6
  M7


M0 M1 M2 M3 M4 M5 M6 M7


AMML (M4)

Acute Myelomonocytic Leukemia

  • Second most common form of AML.

  • Cells are characterized by both granulocytic and monocytic differentiation (color plate 157 and 158).

  • On Romanowsky stained smear it is usually easy to find cells with primary granules (granulocytic differentiation) as well as cells with folded nuclei and moderate to abundant cytoplasm (monocytic differentiation).

  • Peroxidase, sudan black, and NSE positive in 20 to 80% of the cells.

  • When morphologic and cytochemical similarities make the distinction between A$ and A@ difficult, the diagnosis of M4 can be supported by finding a serum lysozyme level exceeding three times the normal level and a peripheral blood monocyte count of greater than 5X10(9)/liter.

PROGNOSIS

Poor

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