Introduction

Leukemia is classified according to cell type with regard to both cell maturity and cell lineage. Cell maturity is used to distinguish between acute and chronic forms, and lineage is used to distinguish between the myeloid and lymphoid leukemias

Learning Objectives

In this module we will review Acute Myeloid Leukemia. Student learning objectives include:

1. Be able to state the names of the seven subtypes of AML



2. State the criteria used by the FAB in the classification of AML subtypes



3. Identify the two subtypes that cannot be classified by FAB criteria and list the criteria used to identify these two subtypes



4. List the two major laboratory methods (other than cytochemistry and morphology) used to enhance the identification of AML subtypes



5. Give a general explanation of all four methods by stating the purpose of each method



6. Be able to state the positive or negative results of each of the following cytochemistry tests (in regard to the 7 subtypes of AML)
   · Myleloperoxidase
   · Sudan Black B
   · Non Specific Esterase
   · Periodic Acid Schiff reaction



7. Given a variety of matching options, (2 to 4 smears and cell names), be able to identify the smears of the following cell types:
   · Myeloblast
   · Melocyte
   · Basophil
   · Eosinophil
   · Neutrophil
   · Megakaryocyte
   · Platelets
   · Erythrocyte

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